Nanocarriers for topical delivery in psoriasis. Singhvi G, Hejmady S, Rapalli VK, Dubey SK, Dubey S.
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Chimex curcuma skin#
Beneficial role of curcumin in skin diseases. Thangapazham RL, Sharma A, Maheshwari RK. Evidence of curcumin and curcumin analogue effects in skin diseases: a narrative review. Panahi Y, Fazlolahzadeh O, Atkin SL, Majeed M, Butler AE, Johnston TP, et al. Curcumin: an age-old anti-inflammatory and anti-neoplastic agent. Nanoformulations of curcumin: an emerging paradigm for improved remedial application. Gera M, Sharma N, Ghosh M, Huynh DL, Lee SJ, Min T, et al. Furthermore, preclinical studies and patents have also indicated the emerging commercialization potential of curcumin-loaded lipid nanocarriers for effective drug delivery in skin disorders. This review particularly focuses on the application of lipid nanocarriers for the topical delivery of curcumin in the treatment of various skin diseases. Nano-size, lipophilic nature, viscoelastic properties, and occlusive effect of lipid nanocarriers provide high drug loading, hydration of skin, stability, enhanced permeation through the stratum corneum, and slow release of curcumin in the targeted skin layers. Lipid-based nanocarrier systems including liposomes, niosomes, solid lipid nanoparticles, nanostructured lipid carriers, lyotropic liquid crystal nanoparticles, lipospheres, and lipid nanocapsules have found potential as carriers to overcome the issues associated with conventional topical dosage forms. However, its low aqueous solubility, poor skin permeation, and degradation hinder its application for commercial use despite its enormous potential.
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The topical delivery of curcumin seems to be more advantageous in providing a localized effect in skin diseases.
![chimex curcuma chimex curcuma](https://www.theherbarie.com/images/product/CurcumaXan.jpg)
It suppresses expression of main inflammatory mediators like interleukins, tumor necrosis factor, and nuclear factor κB which are involved in the regulation of genes causing inflammation in most skin disorders. Curcumin has been reported to act on diverse molecular targets like receptors, enzymes, and co-factors regulate different cellular signaling pathways and modulate gene expression. Curcumin is a unique molecule naturally obtained from rhizomes of Curcuma longa.